Disorder of cardiovascular system

MedGen UID:: 2848
•Concept ID:: C0007222
•: Disease or Syndrome

Synonyms:	Cardiovascular disease; Cardiovascular Disease Risk Factor (Angiotensin Converting Enzyme (ACE)); Cardiovascular Disease Risk Factor (Angiotensin II Receptor, Type 1); Cardiovascular Disease Risk Factor (Angiotensinogen); Cardiovascular Disease Risk Factor (Apolipoprotein E); Cardiovascular Diseases; Cardiovascular disorder
SNOMED CT:	Disorder of cardiovascular system (49601007); CVD - cardiovascular disease (49601007); CVS disease - cardiovascular system disease (49601007); Cardiovascular system disease (49601007); Cardiovascular disorder (49601007); Cardiovascular disease (49601007)

Gene (location): Gene(s) directly associated with this condition or phenotype.	ACE (17q23.3)

Monarch Initiative:	MONDO:0004995

Definition

A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels). Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension. Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDisorder of cardiovascular system
- CROGVMyocardial infarction

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of cardiovascular system
        Abnormality of the cardiovascular system
        Abnormal cardiac test
        Abnormal cardiac biomarker test
        Abnormal cardiac catheterization
        Abnormal cardiac exercise stress test
        Abnormal cardiac MRI
        Abnormal resting energy expenditure from metabolic cart test
        Abnormal cardiovascular system morphology
        Abnormal heart morphology
        Abnormal vascular morphology
        Cardiovascular calcification
        Abnormal cardiovascular system physiology
        Abnormal cardiac atrial physiology
        Abnormal cardiac ventricular function
        Abnormal heart sound
        Abnormal heart valve physiology
        Abnormal systemic blood pressure
        Abnormal vascular physiology
        Abnormality of blood circulation
        Abnormality of cardiovascular system electrophysiology
        Acute coronary syndrome
        Angina pectoris
        Cardiac tamponade
        Chronotropic incompetence
        Congestive heart failure
        Failure to elevate ammonia on ischemic exercise
        Failure to increase oxygen saturation on hyperoxia test
        Presyncope
        Reduced systolic function
        Shock
        Syncope
        Abnormality of the vasculature
        Abnormality of the pulmonary vasculature
        Vascular malformation
        Arterio-Arterial Fistula
        Arteriovenous malformation
        Celiac artery stenosis from compression by median arcuate ligament of diaphragm
        Hereditary hemorrhagic telangiectasia
        May-Thurner syndrome
        Persistent left superior vena cava
        Pulmonary valve atresia
        Scimitar syndrome
        Single umbilical artery
        Vascular Fistula
        Vascular malformation of the nervous system
        Vascular ring
        Cardiovascular neoplasm
        Cardiovascular cancer
        Great vessel cancer
        Heart cancer
        Heart lymphoma
        Malignant Vascular Neoplasm
        Pericardium cancer
        Great Vessel Neoplasm
        Benign Great Vessel Neoplasm
        Neoplasm of the heart
        Benign neoplasm of heart
        Calcified amorphous tumor of the heart
        Cardiac fibroma
        Cardiac germ cell tumor
        Cardiac Inflammatory Myofibroblastic Tumor
        Cardiac myxoma
        Cardiac Paraganglioma
        Cardiac rhabdomyoma
        Cardiac sarcoma
        Cardiac teratoma
        Carney complex
        Neoplasm of endocardium
        Neoplasm of epicardium
        Neoplasm of myocardium
        Neoplasm of pericardium
        Papillary Fibroelastoma
        Vascular Neoplasm
        Angiofibromas
        Angiokeratoma
        Angiosarcoma
        Benign vascular tumor
        Blood vessel neoplasm
        Breast Vascular Neoplasm
        Glomus tumor
        Hemangioma
        Hemangiopericytoma
        Intermediate Vascular Neoplasm
        Kaposi sarcoma
        Lymphatic vessel neoplasm
        Meningioma
        Skin Vascular Neoplasm
        Vascular bone neoplasm
        Heart disease
        Carcinoid heart disease
        Cardiac arrest
        Aborted sudden cardiac death
        Bradycardia Arrest
        Cardiac Arrest Prior to Percutaneous Coronary Intervention
        Cardiac Arrest Requiring Cardiopulmonary Resuscitation
        Cardiac Arrest/Arrhythmia Etiology Unknown
        In-Hospital Cardiac Arrest
        Out-of-Hospital Cardiac Arrest
        Resuscitated Cardiac Arrest Event
        Sudden cardiac death
        Ventricular Tachycardia/Ventricular Fibrillation Arrest
        Cardiac arrhythmia
        Abnormal electrophysiology of sinoatrial node origin
        Abnormal heart rate variability
        Atrial fibrillation
        Atrial flutter
        Bradycardia
        Brugada syndrome
        Commotio Cordis
        Ectopic beats
        First degree atrioventricular block
        Genetic cardiac rhythm disease
        Heart block
        Long QT syndrome
        Palpitations
        Parasystole
        Pre-Excitation Syndrome
        Progressive familial heart block, type 1A
        Second degree atrioventricular block
        Sinus arrhythmia
        Sinus bradycardia
        Sinus tachycardia
        Supraventricular arrhythmia
        Supraventricular tachycardia
        Tachyarrhythmia
        Tachycardia
        Third degree atrioventricular block
        Ventricular arrhythmia
        Ventricular fibrillation
        Ventricular flutter
        Ventricular tachycardia
        cardiac valvular disease
        Aortic valve disorder
        Cardiac valve prolapse
        Cusp Tear
        Heart valve regurgitation
        Leaflet Disruption
        Mitral regurgitation
        Mitral stenosis
        Mitral valve disorder
        Primary Valvular Disorder
        Prosthetic Valve Thrombosis
        Pulmonary valve disorder
        Pulmonary valve insufficiency
        Pulmonary valve stenosis
        Tricuspid atresia
        Tricuspid regurgitation
        Tricuspid stenosis
        Tricuspid valve disorder
        Cardiomegaly
        Cardiomegaly due to hypertension
        Left ventricular hypertrophy
        Primary dilated cardiomyopathy
        Right ventricular hypertrophy
        Cardiomyopathy
        Alcoholic cardiomyopathy
        Arrhythmia-Induced Cardiomyopathy
        Arrhythmogenic right ventricular cardiomyopathy
        Atrial cardiomyopathy
        Chagas cardiomyopathy
        Danon disease
        Diabetic cardiomyopathy
        Endocardial fibroelastosis
        Endomyocardial fibrosis
        Histiocytoid cardiomyopathy
        Hypertrophic cardiomyopathy
        Idiopathic cardiomyopathy
        Idiopathic giant cell myocarditis
        Kearns-Sayre syndrome
        Myocardial Reperfusion Injury
        Myocarditis
        Noncompaction cardiomyopathy
        Peripartum cardiomyopathy
        Primary familial hypertrophic cardiomyopathy
        Restrictive cardiomyopathy
        Sarcoglycanopathy
        Takotsubo cardiomyopathy
        Transthyretin Amyloid Cardiomyopathy
        Conduction disorder of the heart
        Cor pulmonale
        Decreased cardiac output
        Endocarditis
        Acute endocarditis
        Bacterial endocarditis
        Early Prosthetic Valve Endocarditis
        Endocarditides, Non-Infective
        Infective endocarditis
        Late Prosthetic Valve Endocarditis
        Libman-Sacks lesions
        Native Valve Endocarditis
        Prosthetic valve endocarditis
        Subacute bacterial endocarditis
        Heart aneurysm
        Heart failure
        Cardiac edema
        Cardio-renal syndrome
        Diastolic heart failure
        Left heart failure
        Paroxysmal dyspnea
        Systolic heart failure
        Increased cardiac output
        Myocardial ischemia
        Coronary heart disease
        Kounis Syndrome
        Myocardial infarction
        Myocardial rupture
        Post Infarct Cardiac Rupture
        Myocardial stunning
        Non-Neoplastic Heart Disorder
        Atrial Septum Lipomatous Hypertrophy
        Cardiac sarcoidosis
        Chronic pulmonary heart disease
        Congenital heart disease
        Constrictive pericarditis
        Coronary artery disorder
        Coronary microvascular disorder
        Hamartoma of Mature Cardiac Myocytes
        Idiopathic spontaneous coronary artery dissection
        Inflammation of heart layer
        Myocardial disorder
        Myocardial fibrosis
        Post-pericardiotomy syndrome
        Primary eosinophilic endomyocardial restrictive cardiomyopathy
        Rheumatic heart disease
        Short QT syndrome
        Sick sinus syndrome
        Single ventricle
        Structural Heart Abnormality
        Pericardial effusion
        Chylopericardium
        Hemopericardium
        Pericardial effusion co-occurrent and due to malignant neoplasm of pericardium
        Serous pericardial effusion
        Pericarditis
        Acute pericarditis
        Bacterial pericarditis
        Malignant Pericarditis
        Mycotic pericarditis
        Pericardial tuberculosis
        Pericarditis secondary to uremia
        Viral pericarditis
        Pneumopericardium
        Post-cardiac arrest syndrome
        Ventricular Dysfunction
        Abnormal left ventricular function
        Right Ventricular Dysfunction
        Ventricular Outflow Obstruction
        Aortic valve stenosis
        Infectious disease of cardiovascular system
        Cardiovascular syphilis
        Tuberculosis, Cardiovascular
        Non-Neoplastic Cardiovascular Disorder
        Arteriosclerotic Cardiovascular Disease
        Atherosclerosis
        Congenital anomaly of cardiovascular system
        Congenital arteriovenous fistula
        Congenital Coronary Artery Abnormality
        Congenital vascular malformation
        Congenital Vena Cava Abnormality
        Discordant ventriculoarterial connection
        Double outlet right ventricle
        Ectopia cordis
        Great Vessels Abnormality
        Premature closure of the ductus arteriosus
        Shone complex
        Single Ventricle Defect
        Non-Neoplastic Vascular Disorder
        Arterial disorder
        Arteriovenous fistula stenosis
        Cerebrovascular disorder
        Chronic Total Occlusion Vessel
        Diabetic Vascular Disorder
        Embolism
        Hypertensive Episode
        Intimal Dissection Of Blood Vessel
        Ischemic bowel disorder
        Lymphedema
        Moyamoya disease
        Ocular vascular disorder
        Peripheral vascular disease
        Pulmonary Vascular Disorder
        Reactive Vascular Proliferation
        Renal vascular disorder
        STING-associated vasculopathy with onset in infancy
        Thrombotic disease
        Vascular Hemorrhagic Disorder
        Vein disorder
        Pulmonary artery stenosis
        Branch Pulmonary Artery Stenosis
        Congenital stenosis of pulmonary artery
        Peripheral pulmonary artery stenosis
        Supravalvular Pulmonary Artery Stenosis
        Pregnancy Complications, Cardiovascular
        Amniotic fluid embolism
        Thrombotic Disorder
        Thrombophilia
        Disseminated intravascular coagulation
        Hereditary antithrombin deficiency
        Hereditary thrombophilia
        Protein S deficiency disease
        Reduced protein C activity
        Resistance to activated protein C
        Thrombotic thrombocytopenic purpura
        Thrombotic microangiopathy
        Hemolytic-uremic syndrome
        Systemic lupus erythematosus
        Thrombocytopenic purpura
        Transplant-Associated Thrombotic Microangiopathy
        Vascular disorder
        Angiodysplasia
        Vascular ectasia of gastric antrum
        Angioedema
        Hereditary angioneurotic edema
        Angiomatosis
        Angioosteohypertrophic syndrome
        Bacillary angiomatosis
        Breast angiomatosis
        Kasabach-Merritt syndrome
        Sturge-Weber syndrome
        Von Hippel-Lindau syndrome
        Aortic disorder
        Aortic aneurysm
        Aortic arch syndrome
        Aortitis
        Arterial dissection
        Hypoplastic aortic arch
        Leriche syndrome
        Arterial occlusive disease
        Arteriosclerosis disorder
        Carotid artery stenosis
        Fibromuscular dysplasia
        Malignant atrophic papulosis
        Mesenteric vascular occlusion
        Popliteal entrapment syndrome
        Renal artery obstruction
        Retinal arterial occlusion
        Thromboangiitis obliterans
        Capillary leak syndrome
        Carotid artery disorder
        Carotid artery dissection
        Carotid artery thrombosis
        Carotid cavernous fistula
        Compartment syndrome
        Anterior compartment of tibia syndrome
        Chronic Exertional Compartment Syndrome
        Intra-Abdominal Hypertension
        Volkmann contracture
        Embolism and Thrombosis
        Thromboembolism
        Hemorrhoid
        External hemorrhoids
        Internal hemorrhoid
        Hepatic vascular disorder
        Hepatic hemangioma
        Hepatic veno-occlusive disease
        Liver angiosarcoma
        Liver Epithelioid Hemangioendothelioma
        Liver Kaposi Sarcoma
        Liver Lymphangioma
        Liver Lymphangiomatosis
        Hyperemia
        Hypertensive disorder
        Borderline Hypertension
        Chronic Maternal Hypertension
        Chronic Maternal Hypertension with Superimposed Preeclampsia
        Diastolic hypertension
        Episodic hypertension
        Essential hypertension
        Hypertension associated with pheochromocytoma
        Hypertension resistant to conventional therapy
        Hypertension secondary to endocrine disorder
        Hypertension, pregnancy-induced
        Hypertensive crisis
        Hypertensive retinopathy
        Labile Hypertension
        Labile hypertension due to being in a clinical environment
        Malignant hypertension
        Masked Hypertension
        Neonatal hypertension
        Ocular hypertension
        Page kidney
        Paroxysmal hypertension
        Portal hypertension
        Postoperative hypertension
        Postpartum Hypertension
        Pulmonary hypertension
        Renal hypertension
        Secondary hypertension
        Systolic hypertension
        Uncomplicated Hypertension
        Unspecified Antepartum Hypertension
        Hypotension
        Decreased diastolic blood pressure
        Decreased systolic blood pressure
        Drug-induced hypotension
        Hypotension due to Cardiac Dysfunction
        Low-to-normal blood pressure
        Orthostatic hypotension
        Post-Exercise Hypotension
        Shy Drager Syndrome
        Insufficiency, Mesenteric Vascular
        Ischemic colitis
        Ischemic optic neuropathy
        Patent ductus arteriosus
        Bilateral ductus arteriosus
        Patent ductus arteriosus after birth at term
        Patent ductus arteriosus after premature birth
        Peliosis hepatis
        Prehypertension
        Pulmonary vein stenosis
        Pulmonary venoocclusive disease
        Familial pulmonary capillary hemangiomatosis
        Pulmonary venoocclusive disease 1
        Retinal vein occlusion
        Branch retinal vein occlusion
        Central retinal vein occlusion
        Hemiretinal vein occlusion
        Partial retinal vein occlusion
        Spinal Cord Vascular Diseases
        Spinal cord ischemia
        Spinal Vascular Disorder
        Splenic infarction
        Superior vena cava syndrome
        Telangiectasia
        Ataxia-telangiectasia syndrome
        CREST syndrome
        Cutaneous telangiectasia
        Cutis marmorata
        Diffuse telangiectasia
        Exudative retinopathy
        Mucosal telangiectasiae
        Telangiectasia macularis eruptiva perstans
        Telangiectasia of the skin
        Thoracic outlet syndrome
        Arterial thoracic outlet syndrome
        Arterial thoracic outlet syndrome due to cervical rib
        Neurogenic thoracic outlet syndrome
        Venous thoracic outlet syndrome
        Varicocele
        Varicose disease
        Stasis ulcer
        Varicose veins of lower extremity
        Venous varicosities of celiac and mesenteric vessels
        Vulval varicose vein
        Vascular anomaly of eyelid
        Eyelid capillary hemangioma
        Vascular dilatation
        Aneurysm due to traumatic injury
        Aneurysm, Infected
        Arteriovenous fistula aneurysm
        Arteriovenous graft aneurysm
        Brachiocephalic artery aneurysm
        Cerebral aneurysm
        Coronary aneurysm
        Dilatation of the ventricular cavity
        Iliac artery aneurysm
        Intracranial Aneurysm
        Microaneurysm
        Mycotic aneurysm
        Persistent flow of blood into aneurysm sac following endovascular insertion of stent graft
        Pseudoaneurysm
        Retinal arterial macroaneurysms
        Ruptured aneurysm
        Ventricular aneurysm
        Vascular disorder of intestine
        Vascular disorder of penis
        Penile Angiosarcoma
        Penile Epithelioid Hemangioendothelioma
        Penile Hemangioma
        Penile Kaposi Sarcoma
        Penile Lymphangioma
        Vascular hemostatic disease
        Cavernous hemangioma
        Cryoglobulinemia
        Ehlers-Danlos syndrome
        Hyperglobulinemic purpura
        Immunoglobulin A vasculitis
        Multiple myeloma
        Pseudoxanthoma elasticum
        Scurvy
        Shwartzman phenomenon
        Waldenstrom macroglobulinemia
        Vascular neoplasm
        Vascular skin abnormality
        Acute febrile mucocutaneous lymph node syndrome
        Angioma serpiginosum
        Ataxia-telangiectasia-like disorder 1
        Behcet disease
        Blue rubber bleb nevus
        Bockenheimer syndrome
        Calciphylaxis cutis
        Chilblain lupus
        Cobb syndrome
        Congenital livedo reticularis
        Cutaneous collagenous vasculopathy
        Erythema
        Fabry disease
        Familial chilblain lupus
        Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome
        Familial multiple nevi flammei
        Giant cell arteritis
        Hereditary benign telangiectasia
        Livedo
        Livedo reticularis
        Livedoid vasculopathy
        Maffucci syndrome
        Megalencephaly-capillary malformation-polymicrogyria syndrome
        Non-pruritic urticaria
        Polyarteritis nodosa
        Prominent superficial blood vessels
        Pyoderma gangrenosum
        Sneddon syndrome
        Subcutaneous hemorrhage
        Takayasu arteritis
        Urticaria
        Wyburn-Mason syndrome
        Vasculitis
        Allergic cutaneous vasculitis
        Arteritis
        Central nervous system vasculitis
        Cogan syndrome
        Fetal Chorionic Vasculitis
        Granulomatosis with polyangiitis
        Leukocytoclastic vasculitis
        Necrotizing vasculitis
        Phlebitis
        Retinal vasculitis
        Umbilical Vasculitis
        Unclassified vasculitis
        Vasculitis by anatomical site
        Vasculitis by histology
        Vasculitis in the skin
        Vasculitis of systemic vasculature
        Vasoplegia
        Venous insufficiency
        Post-thrombotic syndrome
        Venous stasis syndrome
        Venous occlusion

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Curated

UK NICE Guideline NG238, Cardiovascular disease: risk assessment and reduction, including lipid modification, 2023

UK NICE Guidance, Clinical Guideline CG181, Cardiovascular disease: risk assessment and reduction, including lipid modification, 2023

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Etiology

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Disorder of cardiovascular system

Definition

Term Hierarchy

Professional guidelines

PubMed

Curated

UK NICE Guideline NG238, Cardiovascular disease: risk assessment and reduction, including lipid modification, 2023

UK NICE Guidance, Clinical Guideline CG181, Cardiovascular disease: risk assessment and reduction, including lipid modification, 2023

Recent clinical studies

Etiology

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Clinical resources

Practice guidelines

Curated

Molecular resources

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